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KMID : 0191120160310091491
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Journal of Korean Medical Science
2016 Volume.31 No. 9 p.1491 ~ p.1498
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A Randomized Controlled Trial of Compression Rates during Cardiopulmonary Resuscitation
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Hwang Sung-Oh
Cha Kyoung-Chul
Kim Kyu-Seok
Jo You-Hwan
Chung Sung-Phil
You Je-Sung
Shin Jong-Hwan
Lee Hui-Jai
Park Yoo-Seok
Kim Seung-Hwan
Choi Sang-Cheon
Park Eun-Jung
Kim Won-Young
Seo Dong-Woo
Moon Sung-Woo
Han Gap-su
Choi Han-Sung
Kang Hyung-Goo
Park Seung-Min
Kwon Woon-Yong
Choi Eun-Hee
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Abstract
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The objective of this study was to compare the efficacy of cardiopulmonary resuscitation (CPR) with 120 compressions per minute (CPM) to CPR with 100 CPM in patients with non-traumatic out-of-hospital cardiac arrest. We randomly assigned patients with non-traumatic out-of-hospital cardiac arrest into two groups upon arrival to the emergency department (ED). The patients received manual CPR either with 100 CPM (CPR-100 group) or 120 CPM (CPR-120 group). The primary outcome measure was sustained restoration of spontaneous circulation (ROSC). The secondary outcome measures were survival discharge from the hospital, one-month survival, and one-month survival with good functional status. Of 470 patients with cardiac arrest, 136 patients in the CPR-100 group and 156 patients in the CPR-120 group were included in the final analysis. A total of 69 patients (50.7%) in the CPR-100 group and 67 patients (42.9%) in the CPR-120 group had ROSC (absolute difference, 7.8% points; 95% confidence interval [CI], -3.7 to 19.2%; P = 0.183). The rates of survival discharge from the hospital, one-month survival, and one-month survival with good functional status were not different between the two groups (16.9% vs. 12.8%, P = 0.325; 12.5% vs. 6.4%, P = 0.073; 5.9% vs. 2.6%, P = 0.154, respectively). We did not find differences in the resuscitation outcomes between those who received CPR with 100 CPM and those with 120 CPM. However, a large trial is warranted, with adequate power to confirm a statistically non-significant trend toward superiority of CPR with 100 CPM.
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KEYWORD
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Cardiopulmonary Resuscitation, Cardiac Arrest, Basic Life Support
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